IL-12B Promoter Polymorphism Associated with Asthma and IL-12B Transcriptional Activity
نویسندگان
چکیده
منابع مشابه
Genetic Variations of IL-12B, IL-12Rβ1, IL-12Rβ2 in Behcet's Disease and VKH Syndrome
PURPOSE To investigate the associations of single nucleotide polymorphisms (SNPs) of three genes (IL-12B, IL-12Rβ1 and IL-12Rβ2) in Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population. METHODS A total of 806 BD cases, 820 VKH patients, and 1600 healthy controls were involved in this study. The first investigation included 400 BD patients, 400 VKH cases, a...
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The aim of our study was to investigate the association between common polymorphisms in interleukin-12 (IL-12) and rheumatoid arthritis (RA) risk using meta-analysis. A search was conducted in the PubMed database, covering all papers published by October 14, 2015. Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the strength of this association. Publication bias was asse...
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BACKGROUND IL-12B is a strong candidate gene for asthma. OBJECTIVES We investigated the relationship between IL-12B and asthma, allergic rhinitis, familial asthma, and levels of eosinophils and total immunoglobulin (Ig) E in the serum of asthma patients. METHODS The study group consisted of 53 asthma patients and 60 control patients. Serum total IgE levels, eosinophil count, and the presenc...
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Interleukin (IL)-12 is a key factor in cell-mediated immunity that drives the development of Th1 cells and stimulates T lymphocytes and natural killer cells to produce interferon (INF)-gamma. The IL-12B gene, which encodes the p40 subunit of IL-12, is located at chromosome 5q31-33 and a linkage finding for autoimmune thyroid disease (AITD) on 5q31-33 in a Japanese population has been reported. ...
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Genetic variants in IL12B, encoding the p40 subunit common in interleukin-12 (IL-12) and interleukin-23, were identified as the susceptibility loci for inflammatory bowel disease (IBD). This study aimed to identify the correlation of serum IL-12B expression with disease activity in patients with IBD and evaluate the possibility of IL-12B as a biomarker for assessing inflammatory status in IBD.A...
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ژورنال
عنوان ژورنال: Allergology International
سال: 2005
ISSN: 1323-8930
DOI: 10.2332/allergolint.54.451